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1961年,de Wardener等就开始寻找一种能促进肾脏水盐排泄的利钠激素,并从多种动物的血和尿中分离到具有利钠作用的物质。在实验中使血容量或细胞外液量增加时,这种物质的浓度也随之上升,但不清楚这种物质来自何种组织和器官。1956年Kisch、1964年Jamieson等先后发现在哺乳动物心房的心肌细胞中,存在一种特殊的分泌颗粒,但并不存在于心室细胞。这些颗粒与已知的贮存多肽激素的颗粒有相同的组织学及染色特性,用组织化学方法证实颗粒中存在含硫氨基酸及吲哚化合物。时隔多年,de Bold等及Sonnenberg
In 1961, de Wardener and others began to search for a sodium natriuretic hormone that can promote the excretion of water and salt in the kidneys and to separate the natriuretic substances from the blood and urine of various animals. When blood volume or extracellular fluid is increased during the experiment, the concentration of this substance also rises, but it is unclear what kind of tissues and organs it originates from. 1956 Kisch, 1964 Jamieson, etc. have found in mammalian atrial myocardial cells, there is a special secretory granules, but does not exist in ventricular cells. These particles have the same histological and staining properties as the known polypeptide-storing hormone particles, and histochemical confirmation of the presence of sulfur-containing amino acids and indoles in the particles. After years, de Bold and Sonnenberg