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目的探讨超早期脑梗死应用尿激酶溶栓的临床疗效。方法随机将2010-12-2011-06收治的超早期(发病6h内就诊)急性脑梗死患者67例分为实验组33例、对照组34例。两组均给予抗血小板药物、血管扩张剂等常规治疗,实验组在常规治疗前先进行尿激酶静脉滴注溶栓治疗。结果治疗1个月后实验组总有效率为84.85%,对照组总有效率为64.71%,两组总有效率比较差异有统计学意义(χ2=6.71,P<0.05)。治疗期间两组再出血率、病死率差异均无统计学意义(P>0.05)。结论超早期给予急性脑梗死患者尿激酶静脉滴注溶栓治疗疗效显著,患者神经功能改善明显,值得临床应用。
Objective To investigate the clinical effect of urokinase thrombolysis in patients with ultra-early cerebral infarction. Methods A total of 67 cases of acute cerebral infarction (ultra-early stage within 6 hours of onset) admitted from 2010-12-2011-06 were divided into experimental group (33 cases) and control group (34 cases). Both groups were given antiplatelet drugs, vasodilators and other conventional treatment, the experimental group prior to conventional treatment of urokinase intravenous infusion of thrombolytic therapy. Results One month after treatment, the total effective rate was 84.85% in the experimental group and 64.71% in the control group. The total effective rate was significantly different between the two groups (χ2 = 6.71, P <0.05). There was no significant difference in rebleeding rate and case fatality between the two groups during the treatment (P> 0.05). Conclusion Ultra-early acute cerebral infarction patients with intravenous infusion of urokinase thrombolytic therapy significant effect in patients with significant improvement of neurological function, it is worth clinical application.