空腹时十二指肠腔内pH可为1～7。间断的酸刺激可以触发十二指肠粘膜产生适应性细胞保护反应,并释放出前列腺素。本研究旨在调查食物中脂肪酸能否影响十二指肠粘膜耐酸作用。 在标准配方饮食基础上,添加2％(wt/wt)的油酸或亚油酸或二十碳五烯酸分别制成3种饲料。选用110～120 g的雄性大白鼠180只,随机分组各喂饲1种饲料至少4周。麻醉 Fasting duodenal cavity pH can be 1 ~ 7. Intermittent acid stimulation can trigger the duodenal mucosa to produce adaptive cytoprotective responses and release prostaglandins. The aim of this study was to investigate whether fatty acids in food affect the acid resistance of duodenal mucosa. On the basis of the standard formula diet, 3 kinds of feedstuffs were respectively prepared by adding 2% (wt / wt) oleic acid or linoleic acid or eicosapentaenoic acid. A total of 180 male rats (110-120 g) were randomly divided into four groups. anesthesia