OBJECTIVE To investigate the regulative effect of aqueous extract of Eichhornia crassipes on the oxygen uptake capacity and motion responses of mice under wet/cool stress. METHODS KM mice were randomly divided into normal control group,model control group,Eichhornia crassipes lowdose group(0.5g·kg-1)and high dose group(1.5g·kg-1),then performed intragastric administration for a period of 7d.Wet/cold stressed mice model was established using repeated intermittent(3h·d-1,consecutive 7d)exposure method by placing mice into the exposure box which was covered by ice at the bottom(T<0℃;RH>85%).Oxygen consumption was observed during exposure.Inclined plane method(muscle coordination capacity test)was performed immediately after exposure.60-second video of exhaustive swimming(to calculate swimming speed)was taken 1hafter the last exposure,the exhaustive swimming time was recorded.RESULTS(1)Compared with normal control group,model control group showed significant improvement in oxygen consumption(P<0.01),with an increase up to 77.33%,while inclined plate time,swimming speed and exhaustive swimming time showed significant reduction(P<0.01),at the rates 46.3%,8.54% and 19.68%respectively.(2)Compared with normal control group,Eichhornia crassipes low dose group and high dose group both improved oxygen consumption significantly(P<0.01),at rates of 10.93% and 90.38%respectively.This indicated high-dose aqueous extract of Eichhornia crassipes could fulfil actual oxygen demand of wet/cold stressed mice effectively.Inclined plate and exhaustive swimming experiments indicated that low-dose aqueous extract of Eichhornia crassipes boosted physical power significantly,as its exhaustive swimming time was increased up to 56.61%.Meanwhile,high-dose aqueous extract of Eichhornia crassipes has significant regulative effect on muscle coordination capability and motion speed,which were increased by 17.38% and 11.17%,respectively.CONCLUSION Aqueous extract of Eichhornia crassipes has definite regulative effect on the oxygen uptake capacity and motion responses of wet/cold stressed mice.Aqueous extract of Eichhornia crassipes can achieve stress protective effect by improving oxygen uptake capacity,muscle coordination capacity and motion abilities. OBJECTIVE To investigate the regulative effect of aqueous extract of Eichhornia crassipes on the oxygen uptake capacity and motion responses of mice under wet / cool stress. METHODS KM mice were randomly divided into normal control group, model control group, Eichhornia crassipes low dose group (0.5 g · Kg-1) and high dose group (1.5g · kg-1), then performed intragastric administration for a period of 7d.Wet / cold stressed mice model was established using repeated intermittent (3h · d-1, consecutive 7d) exposure method by placing mice into the exposure box which was covered by ice at the bottom (T <0 ° C; RH> 85%). Oxygen consumption was observed during exposure.Inclined plane method (muscle coordination capacity test) was performed immediately after exposure. 60-second video of exhaustive swimming (to calculate swimming speed) was taken 1hafter the last exposure, the exhaustive swimming time was recorded .RESULTS (1) Compared with normal control group, model control group showed significant improvement in oxygen cons (P <0.01), with an increase up to 77.33%, while inclined plate time, swimming speed and exhaustive swimming time showed significant reduction (P <0.01), at rates 46.3%, 8.54% and 19.68% respectively. ) Compared with normal control group, Eichhornia crassipes low dose group and high dose group both improved oxygen consumption significantly (P <0.01), at rates of 10.93% and 90.38% respectively.This indicated high-dose aqueous extract of Eichhornia crassipes could fulfill actual oxygen demand of wet / cold stressed mice effectively.Inclined plate and exhaustive swimming experiments that that low-dose aqueous extract of Eichhornia crassipes boosted physical power significantly, as its exhaustive swimming time was increased up to 56.61% .Meanwhile, high-dose aqueous extract of Eichhornia crassipes has significant regulative effect on muscle coordination capability and motion speed, which were increased by 17.38% and 11.17%, respectively.CONCLUSION Aqueous extract of Eichhornia crassipes has defin ite regobic effect on the oxygen uptake capacity and motion responses of wet / cold stressed mice. Aqueous extract of Eichhornia crassipes can achieve stress protective effect by improving oxygen uptake capacity, muscle coordination capacity and motion abilities.