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除草剂胺草灵的迟发性神经毒性试验时发现睾丸明显萎缩,睾丸脏器系数比对照组小5~6倍,小鼠睾丸细胞染色体畸变分析,对精母细胞有诱变作用;显性致死试验,在100mg/kg时对小鼠初级精母细胞有显性致死效应。为进一步验证胺草灵对生殖细胞的影响,又进行了小鼠精子畸变试验。实验动物用C57雄性小黑鼠,体重20~25g,共分6个组,即空白对照组、食油对照组、环磷酰胺(30mg/kg)阳性对照组及胺草灵100、20、4 mg/kg组,除环磷酰胺腹腔
Herbicide amikacin delayed neurotoxicity test showed significant testicular atrophy, testis organ coefficient 5 to 6 times smaller than the control group, mouse testicular cell chromosome aberration analysis of spermatocytes mutagenic effect; dominant Lethal test, at 100mg / kg mouse primary spermatocytes have a dominant lethal effect. In order to further verify the effect of Amirenum on germ cells, a mouse sperm aberration test was performed. Experimental animals C57 male black mice, weighing 20 ~ 25g, is divided into 6 groups, namely blank control group, cooking oil control group, cyclophosphamide (30mg / kg) positive control group and amrinone 100,20,4 mg / kg group, except cyclophosphamide abdominal cavity