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目的:采用固体分散技术,提高氢氯噻嗪的体外溶解性能。方法:分别以PEG6000和PVPK30为载体,制备氢氯噻嗪固体分散体。采用紫外分光光度法进行含量测定,差示热分析法鉴别药物在载体中的存在状态,并进行溶解度、体外溶出速率实验。结果:2种载体的固体分散体均能增加药物的溶解度和溶出速率,氢氯噻嗪在载体中以高度分散状态存在。结论:以PVPK30为载体制备的氢氯噻嗪固体分散体体外溶解度和溶出速率明显提高。
Objective: To improve the in vitro solubility of hydrochlorothiazide by solid dispersion technique. Methods: PEG6000 and PVPK30 were used as carriers to prepare solid dispersion of hydrochlorothiazide. UV spectrophotometry was used to determine the content, differential thermal analysis to identify the presence of drug in the carrier, and solubility, in vitro dissolution rate experiments. Results: Solid dispersions of both carriers increased drug solubility and dissolution rate and hydrochlorothiazide was present in highly dispersed state in the carrier. Conclusion: The solid dispersion of hydrochlorothiazide prepared with PVPK30 as carrier has significantly higher in vitro solubility and dissolution rate.