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目的探讨枸橼酸西地那非对妊娠期肺动脉高压患者的影响。方法选取2014年1月—2016年1月荆州市公安县人民医院收治的妊娠期肺动脉高压患者80例,随机分为对照组和观察组,每组40例。对照组患者采用常规治疗,观察组患者在常规治疗基础上给予枸橼酸西地那非治疗。比较两组患者治疗前后肺动脉收缩压、左心室射血分数、血压、心率、血氧饱和度及妊娠结局。结果治疗前两组患者肺动脉收缩压、左心室射血分数比较,差异无统计学意义(P>0.05);治疗后观察组患者肺动脉收缩压低于对照组,左心室射血分数高于对照组(P<0.05)。两组患者治疗前收缩压、舒张压、心率、血氧饱和度及治疗后收缩压、舒张压、心率比较,差异无统计学意义(P>0.05);治疗后观察组患者血氧饱和度高于对照组(P<0.05)。观察组患者顺产、足月分娩者所占比例高于对照组(P<0.05)。结论枸橼酸西地那非有助于降低妊娠期肺动脉高压患者肺动脉收缩压,提高患者左心室射血分数和血氧饱和度,减少不良妊娠结局的发生。
Objective To investigate the effect of sildenafil citrate on patients with pulmonary hypertension during pregnancy. Methods From January 2014 to January 2016, 80 cases of pregnancy-induced pulmonary hypertension in Jingan Gong’an People’s Hospital were randomly divided into control group and observation group, 40 cases in each group. Patients in the control group were treated with conventional therapy. Patients in the observation group were given sildenafil citrate on a routine basis. Before and after treatment, pulmonary artery systolic pressure, left ventricular ejection fraction, blood pressure, heart rate, oxygen saturation and pregnancy outcome were compared between the two groups. Results There was no significant difference in pulmonary artery systolic pressure and left ventricular ejection fraction between the two groups before treatment (P> 0.05). After treatment, pulmonary artery systolic pressure in observation group was lower than that in control group, left ventricular ejection fraction was higher than that in control group P <0.05). Before treatment, systolic blood pressure, diastolic blood pressure, heart rate, blood oxygen saturation and post-treatment systolic blood pressure, diastolic blood pressure and heart rate were not significantly different between the two groups (P> 0.05). After treatment, the oxygen saturation In the control group (P <0.05). Obstetric patients in observation group, the proportion of full-term delivery was higher than the control group (P <0.05). Conclusion Sildenafil citrate helps to reduce pulmonary artery systolic pressure in patients with pulmonary hypertension during pregnancy, improve left ventricular ejection fraction and oxygen saturation, and reduce the incidence of adverse pregnancy outcomes.