地方甲状腺肿是一种分布广泛,发病率高,危害很大的地方病。此病除在少数海滨地区及某些病区是由高碘及致甲状腺肿物质引起外,主要的原因是缺碘。这一点巳由大量流行病学资料所证实。虽然地方甲状腺肿的病因比较明确,但病变发生和演化过程目前仍不十分清楚。目前国外多用人工配制的低碘饮食在实验动物中复制甲状腺肿的模型,来研究甲状腺肿的发生、发展过程及发病机制。国内有关甲状腺肿病变发展的资料,主要是来自手术标本的病理检查,实验研究的报告不多。于志恒及李彦等分别用地方 Local goiter is a widely distributed, high incidence, a devastating endemic disease. In addition to the disease in a few coastal areas and some wards are caused by high iodine and goiter substances, the main reason is iodine deficiency. This has been confirmed by a large body of epidemiological data. Although the cause of local goiter more clear, but the occurrence and evolution of lesions is still not very clear. At present, a model of goiter replicated in laboratory animals by artificial low-iodine diet is used to study the occurrence, development and pathogenesis of goiter. Domestic information on the development of goiter lesions, mainly from the surgical specimens of the pathological examination, the experimental report is not much. Yu Zhiheng and Li Yan, respectively, with the place