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目的探讨P21活化激酶(p21-activated kinase,PAK)group Ⅰ在非小细胞肺癌中的表达模式和意义。方法应用免疫组化及Western Blot方法,分析检测了肺癌组织中PAK Group Ⅰ的表达情况及其与临床病理因素的关系。结果与正常肺组织相比,PAK Group Ⅰ在肺癌组织中出现明显的胞浆过表达67.31%(105/156),并且其异常表达模式与肺癌组织的组织学类型(P=0.027)、高分期(P=0.007)、淋巴结转移(P=0.035)及患者的不良预后(P<0.001)相关。结论肺癌组织中PAK Group Ⅰ蛋白过表达是非小细胞肺癌的恶性程度的重要标志之一。
Objective To investigate the expression pattern and significance of p21-activated kinase (PAK) group Ⅰ in non-small cell lung cancer. Methods Immunohistochemical and Western Blot methods were used to detect the expression of PAK Group Ⅰ in lung cancer and its relationship with clinicopathological factors. Results Compared with normal lung tissue, PAK Group Ⅰ showed significant cytoplasm overexpression in 67.31% (105/156) of lung cancer tissues, and its abnormal expression pattern was correlated with the histological type of lung cancer (P = 0.027), high stage (P = 0.007), lymph node metastasis (P = 0.035), and poor prognosis in patients (P <0.001). Conclusion PAK Group Ⅰ protein overexpression in lung cancer is one of the important markers of the malignancy of non-small cell lung cancer.