Glucose is the mainly nutrient substances in tumor growth,which played an important role in tumor cells’ growth,proliferation and immigration.Numerical simulation will help a good understanding for the influence of glucose which affected on a vascular solid tumor growth.We present a hybrid on-Lattice Model to simulate the influence of glucose on a-vascular tumor growth.The hybrid model we developed focuses on five key variables implicated in the invasion process:tumor cells,extracellular matrix,matrix-degradative enzymes,oxygen and glucose.And about the discrete model,we consider cell evolution dynamics on cell level.Results indicate that the number of proliferation and quiescent cells is decreasing by decreasing the initial glucose concentration,consequently increase necrotic area relatively.Thus there is inhabitation effect on tumor growth by decreasing initial glucose concentration. Glucose is the mainly nutrient substances in tumor growth, which played an important role in tumor cells’ growth, proliferation and immigration. Numerical simulation will help a good understanding for the influence of glucose which affected on a vascular solid tumor growth. We present a hybrid on-Lattice Model to simulate the influence of glucose on a-vascular tumor growth. The hybrid model we developed focuses on five key variables implicated in the invasion process: tumor cells, extracellular matrix, matrix-degradative enzymes, oxygen and glucose. About about the discrete model, we consider cell evolution dynamics on cell level. Results indicate that the number of proliferation and quiescent cells is decreasing by decreasing the initial glucose concentration, increasing increase necrotic area relatively. Thus there is inhabitation effect on tumor growth by decreasing initial glucose concentration.