100年前,Koch 对霍乱进行了开创性的研究工作,但至今霍乱仍使许多流行病学家感到迷惑不解,许多国家甚至反对采取一些控制措施。作者就霍乱流行病学提出了一种新的模式,此模式符合现代知识,并能在研究工作中得到证实。地方性霍乱的维持与流行性霍乱不同,要对地方性霍乱下个确切的定义是困难的。霍乱可在一个区域内流行,在此区域内病例经常发生,但未必连续发生,每次发病时,没有输入的证据, 100 years ago, Koch pioneered the research on cholera, but so far cholera has puzzled many epidemiologists and many countries even oppose some control measures. The authors propose a new model of cholera epidemiology that is consistent with modern knowledge and validated in research efforts. The maintenance of endemic cholera is different from epidemic cholera, and the exact definition of endemic cholera is difficult. Cholera can be endemic in an area where cases often occur, but not necessarily in a row, with no evidence of each entry,