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目的探讨农村青年和中年妇女宫颈人乳头状瘤病毒(human papilloma virus,HPV)感染情况及其与宫颈病变的关系。方法采用荧光定量聚合酶链式反应(polymerase chain reaction,PCR)方法对来聊城市第三人民医院就诊的农村中青年妇女行宫颈高危型HPV16/18亚型检测和宫颈口病理检查。结果筛选出宫颈病变患者488例。其中青年妇女患者188例,宫颈癌25例,HPV(+)21例,占84.0%;非宫颈癌病变163例,HPV(+)150例,占92.0%。中年妇女患者300例,宫颈癌45例,HPV(+)15例,占33.3%;非宫颈癌255例,HPV(+)105例,占41.2%。宫颈病变与宫颈癌患者中,青年组HPV阳性率均显著高于中年组,差异有统计学意义(P<0.05)。结论农村青年妇女HPV感染率较中年妇女高,对宫颈癌发病影响较大,故应该对青年妇女加强检测,定期随访。
Objective To investigate the status of cervical papilloma virus (HPV) infection in rural youth and middle-aged women and its relationship with cervical lesions. Methods High-risk cervical HPV16 / 18 subtype and cervix pathology were examined in rural middle-aged and young women who came to Liaocheng Third People’s Hospital by fluorescence quantitative polymerase chain reaction (PCR). Results 488 cervical lesions were screened out. There were 188 cases of young women, 25 cases of cervical cancer, 21 cases of HPV (+), accounting for 84.0%; 163 cases of non-cervical cancer and 150 cases of HPV (92.0%). There were 300 cases of middle-aged women, 45 cases of cervical cancer, 15 cases of HPV (+), accounting for 33.3%; 255 cases of non-cervical cancer, 105 cases of HPV (41.2%). In cervical lesions and cervical cancer patients, the HPV positive rate in young group was significantly higher than that in middle age group, the difference was statistically significant (P <0.05). Conclusion The prevalence of HPV infection among young rural women is higher than that of middle-aged women and has a greater impact on the incidence of cervical cancer. Therefore, young women should be tested and regularly followed up.