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目的:探讨试管婴儿的安全性、异常婴儿发育以及低体重儿出生的风险,并对其作出分析。方法:对于2007-2011年间辅助生殖技术受孕的1813例婴儿,按其借助的IVF-ET,ICSI-ET,F-ET技术分成三组,对试管婴儿出生缺陷情况及低体重儿分布情况进行分析。结果:IVF的新生儿缺陷率与ICSI组的缺陷率无明显差异,而F-ET组的新生儿缺陷率却低于前两组。不同的辅助生殖技术造成新生儿缺陷不存在统计学意义。借助不同助孕技术出生的婴儿中,低体重婴儿的分布没有明显差异,但是单胎婴儿或双胎婴儿的体重分布存在差别。结论:不同辅助生殖技术受孕的试管婴儿出生缺陷无显著性差别,单胎还是双胎会对试管婴儿低体重造成影响。
OBJECTIVE: To investigate the safety of IVF, abnormal infant development and the risk of low birth weight infants, and to analyze them. Methods: A total of 1813 infants fertilized with assisted reproductive technology during 2007-2011 were divided into three groups according to IVF-ET, ICSI-ET and F-ET techniques. The incidence of birth defects and the distribution of low birth weight infants were analyzed. . Results: There was no significant difference in neonatal defect rate between IVF group and ICSI group, but the F-ET group’s neonatal defect rate was lower than the former two groups. There is no statistical significance of neonatal defects caused by different assisted reproductive technologies. There was no significant difference in the distribution of low-birth-weight infants among infants born with different fertilization techniques, but there was a difference in body weight distribution among singleton or twin infants. CONCLUSIONS: There was no significant difference in birth defects among IVF conceived with different assisted reproductive technologies. Singletons or twin pregnancies had an impact on IVF in IVF.