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目的研究细胞间粘附分子-1(ICAM-1)、信号传导和转录激活因子4(STAT4)在胃腺癌中的表达及临床意义。方法应用免疫组化S-P法检测60例胃腺癌手术切除标本,其中维吾尔族30例,汉族30例,所有患者术前未行放疗和化疗。另选切端正常粘膜组织15例作对照。以上病例均经病理检查,诊断明确无误。观察ICAM-1、STAT4在胃腺癌中的表达及其与临床的关系。结果(1)60例胃腺癌组织中ICAM-1、STAT4的表达阳性检出率分别为:51.7%(31/60)、35.0%(21/60),ICAM-1、STAT4的表达与分化程度呈负相关,ICAM-1在胃腺癌淋巴结有癌转移阳性表达高于无癌转移,统计学有显著性差异,STAT4在淋巴结有无转移组的表达无显著差异。ICAM-1、STAT4的表达与胃癌临床分期呈负相关。结论提示ICAM-1、STAT4的表达与胃腺癌的恶性程度、临床分期有相关性,可能参与了胃癌的发展与转移过程,可以作预后参考指标。
Objective To study the expression of ICAM-1, signal transducers and activators of transcription 4 (STAT4) in gastric adenocarcinoma and its clinical significance. Methods Sixty cases of gastric adenocarcinoma were examined by immunohistochemical S-P method. Among them, 30 cases were Uygur nationality and 30 Han nationality. All patients underwent radiotherapy and chemotherapy before operation. Another cut end of normal mucosa tissue as control. The above cases were pathologically examined, the diagnosis is clear. To observe the expression of ICAM-1 and STAT4 in gastric adenocarcinoma and their clinical significance. Results (1) The positive rates of ICAM-1 and STAT4 expression in 60 cases of gastric adenocarcinoma were 51.7% (31/60) and 35.0% (21/60) respectively. The expression and differentiation of ICAM-1 and STAT4 Negative correlation, ICAM-1 in gastric adenocarcinoma lymph node metastasis positive expression was higher than no cancer metastasis, statistical significant difference, STAT4 in lymph node metastasis group no significant difference. The expression of ICAM-1 and STAT4 was negatively correlated with the clinical stage of gastric cancer. Conclusions The expression of ICAM-1 and STAT4 is correlated with the degree of malignancy and clinical stage of gastric adenocarcinoma, and may be involved in the development and metastasis of gastric cancer.