作者描述四例慢性氯普馬嗪性黄疸患者,黄疸持續7到56个月。临床表現为持續性阻塞性黄疸、脂肪痢和体重减輕。三例患者表现为黄色瘤病。生物化学变化包括血清胆固醇和血清碱性磷酸酶于疾病早期开始明显增高。临床表现类似原发性胆汁性肝硬化,但是发作较急,并且能詢問出有接受药物損害的历史。所有四例患者結果临床均得到恢复,与之对比的原发性胆汁性肝硬化则常不可避免地要致命。黄疸消退后几个月內,血清碱性磷酸酶和血清胆固醇仍然增 The authors describe four patients with chronic cloprolazine jaundice that lasts between 7 and 56 months. Clinical manifestations of persistent obstructive jaundice, steatorrhea and weight loss. Three patients showed xanthomatosis. Biochemical changes, including serum cholesterol and serum alkaline phosphatase, were markedly elevated early in the disease. Clinical manifestations are similar to primary biliary cirrhosis but seizures are more acute and can ask for a history of drug damage. All four patients recovered clinically, whereas primary biliary cirrhosis was often inevitably fatal. Within a few months after jaundice subsides, serum alkaline phosphatase and serum cholesterol are still increasing