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研究3种免疫增强剂对动物免疫功能及睡眠的影响。给小鼠注射异丙肌普，一周后其脾淋巴细胞转化能力增强，腹腔巨噬细胞释放IL－1和TNF的能力增强，戊巴比妥钠诱导的睡眠时间明显延长；给家兔注射转移因子，一周后其血淋巴细胞转化能力增强，血清TNF水平增加，睡眠时间也明显延长；静脉或脑室内注射胞壁酰二肽，小鼠血清及脑组织中TNF水平增高，可延长家兔睡眠时间。以上结果提示增强免疫功能可延长动物睡眠时间。
The effects of three immune enhancers on immune function and sleep were studied. The mice were injected with isoprivastin, one week after the spleen lymphocyte transformation ability increased peritoneal macrophages release of IL-1 and TNF ability to enhance pentobarbital sodium-induced sleep time was significantly extended to the injection of rabbit transfer Factor, one week later, the hemolymph cell transformation ability increased, serum TNF level increased, sleep time also significantly prolonged; intravenous or intracerebroventricular injection of muramyl dipeptide, mouse serum and brain TNF levels increased, prolonged sleep in rabbits time. The above results suggest that enhancing immune function can prolong animal sleep time.