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采用Ｌａｎｇｅｎｄｏｒｆ离体大鼠心脏灌注，研究全心缺血１０分钟、再灌注１５分钟后，心率、左室发展压、冠脉流率和心电图的变化，以及钙离子拮抗剂盐酸氟桂嗪（ＦＮＺ）和／或氧自由基清除剂维生素Ｃ（Ｖｉｔ．Ｃ）对上述指标的影响。结果发现，ＦＮＺ具冠脉扩张（Ｐ＜０．０１）及轻微负性心率作用；对左室发展压无影响。Ｖｉｔ．Ｃ对心率、左室发展压和冠脉流率均无影响。再灌注１０分钟时，ＦＮＺ＋Ｖｉｔ．Ｃ组、Ｖｉｔ．Ｃ组和ＦＮＺ组的心率与左室发展压乘积（率压积）均显著高于对照组（Ｐ＜０．０５）。提示ＦＮＺ和Ｖｉｔ．Ｃ均可改善再灌注后心脏功能的恢复。
Heart rate, left ventricular ejection fraction, coronary flow rate, and electrocardiogram changes were measured after 10 min of ischemia and 15 min of reperfusion with Langendorf rat heart perfusion. The effects of calcium ion antagonist flunarizine (FNZ ) And / or vitamin free radical scavenger vitamin C (Vit.C) on the above indicators. The results showed that, FNZ with coronary dilation (P <0.01) and a slight negative heart rate; no effect on LV development pressure. Vit. C had no effect on heart rate, LV developmental pressure, and coronary flow rate. At 10 minutes of reperfusion, FNZ + Vit. Group C, Vit. The product of heart rate and LVG (rate-pressure product) in group C and FNZ were significantly higher than those in control group (P <0.05). Prompt FNZ and Vit. C can improve the recovery of cardiac function after reperfusion.