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通过免疫组织化学SP法检测原发性肝癌患者癌及癌旁组织中抑癌基因p53蛋白的表达．揭示其与患者的临床病理改变之间的联系。结果p53蛋白在肝癌及癌旁组织中的检出率分别为30．4％和7.9％（P＜0．05），定位于肝细胞的胞浆内，肝癌细胞的胞核内；p53蛋白表达与癌细胞的分化存在着明显联系（P＜0．05）；而与癌块大小、肝内外转移和播散及患者的预后无关（P＜0．05）。本文提示抑癌基因p53的失活可能参与了肝癌的发生，但与其生物学行为之间的联系不大。
The expression of tumor suppressor gene p53 protein was detected by immunohistochemistry SP method in primary hepatocellular carcinoma. Reveal the link between its clinical pathological changes in patients. Results The detection rates of p53 protein in hepatocellular carcinoma and paracancerous tissues were 30.4% and 7.9%, respectively (P<0.05), and were localized in the cytoplasm of hepatocytes and in the nucleus of hepatoma cells; p53 protein expression was also detected. There was a significant relationship with the differentiation of cancer cells (P<0.05), but there was no correlation with the size of tumors, intrahepatic metastasis and dissemination, and the prognosis of patients (P<0.05). This article suggests that the inactivation of the tumor suppressor gene p53 may be involved in the occurrence of liver cancer, but the relationship between its biological behavior and the biological behavior is not significant.