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本文通过连续记录２４～４８ｈ动态心电图，探讨２２例病者室性早搏（ＶＰＣ）自发变动的特点，发现相邻小时与小时之间ＶＰＣ密度存在着自相关和直线相关关系。以相邻小时之间ＶＰＣ密度自发变动之预测值的９９％可信限，建立个体化药物疗效评价标准。采用安慰剂对照的单盲交叉法进行单次大剂量口服和静脉注射普罗帕酮、单次大剂量口服氟卡胺的临床急性药物试验，同时与目前国内外有关药效评价方法或标准作比较，结果表明，本文设计的方法和标准可靠、安全，较少出现假性药效，不但适用于个体病人选药，而且可为临床提供一种新的更合理的急性非侵入性药物疗效评价方法。
In this paper, continuous 24-48 h Holter recordings were performed to investigate the spontaneous changes of ventricular premature beat (VPC) in 22 patients. There was an autocorrelation and linear correlation between VPC densities between adjacent hours and hours. A 99% confidence limit on the predicted spontaneous change in VPC density between adjacent hours was established to establish an individualized drug efficacy evaluation criteria. Single-blind placebo-controlled crossover method was used to carry out a single large-dose oral and intravenous propafenone, a single large-dose oral flecainide clinical acute drug test, at the same time with the current domestic and international evaluation of efficacy or standards for comparison The results show that the methods and standards designed in this paper are reliable, safe and less prone to false efficacy, which not only applies to individual patients, but also provides a new and more reasonable method for evaluating non-invasive drug efficacy in clinical practice .