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目的 :探讨13 1I治疗甲状腺功能亢进症的最佳治疗方法和减少甲低发生率。方法 :96年 1月至 98年 12月 ,用13 1I分批分次治疗甲亢病人 2 16例 ,首次13 1I治疗剂量 3 7MBq/g ,每月复查一次 ,三个月为一疗程 ,根据临床症状、体征和复查结果增加或减少剂量给予第二或第三疗程治疗 ,随访 18个月以上 ,直至痊愈。结果 :第一疗程治愈 69例 ,第二疗程治愈 82例 ,第三疗程治愈 3 7例第四疗程治愈 2 7例。亚临床甲低 2 4例 ,2 2例恢复正常 ,2例复发 ;临床甲低 16例 ,经甲状腺片替代治疗 ,6例甲低基本恢复 ,10例为永久性甲低 ,给予甲状腺片替代治疗。结论 :13 1I治疗甲亢效果肯定 ,治愈率高 ( 99 5 % ) ,复发率低 ( 2～ 3 % ) ,亚临床甲低发生率为 11 1% ,临床甲低发生为 7 4% ,低于国内外报道
Objective: To explore the best treatment of hyperthyroidism with 131I and reduce the incidence of hypothyroidism. METHODS: From January 1996 to December 1998, 231 patients with hyperthyroidism were treated with 131I in batches. The first 13II treatment dose was 37MBq / g, once a month, three months as a course of treatment. According to the clinical Symptoms, signs and review results increase or decrease the dose given to the second or third course of treatment, followed up for 18 months or more, until cured. Results: The first course of treatment was cured in 69 cases, the second course of cure was 82 cases, the third course of treatment was cured in 37 cases, the fourth course of treatment was 27 cases. Subclinical hypothyroidism in 24 cases, 22 cases returned to normal, 2 cases of recurrence; clinical hypothyroidism in 16 cases, the thyroid replacement therapy, 6 cases of hypothyroidism was basically recovered, 10 cases of permanent hypothyroidism, given thyroid replacement therapy . Conclusion: The treatment of hyperthyroidism with 131I is affirmative, and the cure rate is high (99.5%) and the recurrence rate is low (2-3%). The incidence of subclinical hypothyroidism is 11.1% and that of clinical hypothyroidism is 74% Domestic and foreign reports