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目的 探讨嗅神经母细胞瘤的临床、病理形态学及免疫组化特点。方法 收集 12例嗅神经母细胞瘤的临床资料 ,用普通形态学方法及免疫组化染色观察形态特点。结果 按kadish分期 ,A期无一例 ,B期 7例 ,C期 5例。组织学特征是瘤细胞以片状、梁索状排列 ,有Homer wright、Fle ner菊形团 ,细胞间可见胞浆突起形成的嗜酸性纤维。多种抗体免疫组化染色 :NSE 12例均为阳性 ,S - 10 0 3例阳性 ,NF4例阳性 ,Vimentin 4例阳性 ,LCA、Keratin、HMB - 4 5、Desmin均为阴性。结论 NSE对诊断嗅神经母细胞瘤有特异性价值 ,其它免疫组化联合检测有助于诊断及鉴别诊断。
Objective To investigate the clinical, pathological and immunohistochemical characteristics of olfactory neuroblastoma. Methods The clinical data of 12 cases of olfactory neuroblastoma were collected and the morphological characteristics were observed by the common morphological methods and immunohistochemical staining. Results according to kadish staging, no case of A, B in 7 cases, C in 5 cases. Histological features of the tumor cells to flake, beam-like arrangement, with Homer wright, Fle ner daisy group, visible cytoplasmic cells formed between the eosinophilic fibers. Immunohistochemical staining of various antibodies: NSE 12 cases were positive, S - 10 0 cases were positive, NF4 cases positive, Vimentin 4 cases positive, LCA, Keratin, HMB - 45, Desmin were negative. Conclusion NSE has specific value for the diagnosis of olfactory neuroblastoma, and other immunohistochemical detection is helpful for the diagnosis and differential diagnosis.