HIGH IMMOBILIZATION OF ANTIBACTERIAL MOIETIES ONTO MONODISPERSE MICROSPHERES BY DISPERSION POLYMERIZ

来源 :Chinese Journal of Polymer Science | 被引量 : 0次 | 上传用户:AsiaITt
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In order to achieve monodisperse particles with high content of antibacterial groups covalently bonded on surface, a bicationic viologen,N-hexyl-N’-(4-vinylbenzyl)-4,4’-bipyridinium bromide chloride(HW) was devised as a surfmer in dispersion polymerization of styrene(St) using a mixture of methanol(or ethylene glycol) and water as media.Effects of content of HW,its addition profile and composition of reaction media on particles size and incorporation of HW moieties were mainly investigated.The attachment of silver and gold nanoparticles on particle surface under UV irradiation ascertained the surface-bonded HW segments.SEM,TEM observations and XPS,zata potential measurements indicated that increase of initial HW contents and addition of HW(when polymerization had been performed for 3 h) led to grown particles and enhanced immobilization of HW moieties.Using a mixture of ethylene glycol and water as reaction media, small particles(520-142 nm) with highly attached HW moieties were prepared.Furthermore,antibacterial efficacy of the resultant particles against S.aureus was assayed,and particles with more HW moieties anchored on surface demonstrated greater efficiency of antibacterial activity. In order to achieve monodisperse particles with high content of antibacterial groups covalently bonded to the surface, a bicationic viologen, N-hexyl-N’- (4-vinylbenzyl) -4,4’-bipyridinium bromide chloride (HW) was devised as a surfmer in dispersion polymerization of styrene (St) using a mixture of methanol (or ethylene glycol) and water as media. Effects of content of HW, its addition profile and composition of reaction media on particles size and incorporation of HW moieties were mainly investigated. attachment of silver and gold nanoparticles on particle surface under UV irradiation ascertained the surface-bonded HW segments. SEM, TEM observations and XPS, zata potential measurements indicated that increase of initial HW contents and addition of HW (when polymerization had been performed for 3 h ) led to grown particles and enhanced immobilization of HW moieties. Using a mixture of ethylene glycol and water as reaction media, small particles (520-142 nm) with highly attached HW moieties were prepar ed. Stillrther, antibacterial efficacy of the resultant particles against S. aureus was assayed, and particles with more HW moieties anchored on surface demonstrated greater efficiency of antibacterial activity.
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