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生殖免疫学是随着生殖医学和免疫学进展发展起来的一门新学科,其核心问题是妊娠免疫耐受机制即母体对半同种异型抗原（胚胎）为何不排斥,反而呈接受状态。目前,随着分子生物学及免疫检测技术的发展,对生殖免疫学的研究已从过去的从母体系统免疫状态对此问题的解释延伸到胚胎距母体最近的子宫局部免疫状况。现在发现,胚胎具有一定的免疫原性,孕期母体免疫应答力虽有所下降但仍完整,胎儿出生时,细胞和体液免疫应答均已建立。究竟妊娠免疫耐受的原因何在?本文仅就HCG、T细胞亚群与细胞因子的关系进行简要综述,主要从以下三个方面加以说明。
Reproductive immunology is a new discipline that has developed with the progress of reproductive medicine and immunology. The core issue is the mechanism of immune tolerance in pregnancy, that is, the mother does not reject the semi-alloantigen (embryo), but instead receives the condition. At present, with the development of molecular biology and immunoassay techniques, research on reproductive immunology has extended from the past interpretation of this problem from the immune status of the mother system to the local uterine immune status of the embryo from the mother. Now that the embryo has a certain degree of immunogenicity, maternal immune response during pregnancy, though decreased but still intact, the birth of the fetus, cellular and humoral immune responses have been established. What are the causes of pregnancy immune tolerance? This article only HCG, T cell subsets and cytokines in a brief overview of the relationship, mainly from the following three aspects to be described.