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目的：探讨空心加压螺钉内固定结合富血小板血浆（PRP）骨折端注射治疗中青年人股骨颈骨折的临床疗效。方法分析中青年股骨颈骨折患者25例的临床资料，采用经闭合复位空心钉固定结合 PRP骨折端注射治疗，观察骨折愈合情况及术后并发症发生情况。结果术后随访12～40个月，骨折愈合23例，骨折未愈合2例；根据髋关节功能 Harris 评分标准，优17例，良5例，差3例，优良率88％。结论空心螺钉内固定结合 PRP 骨折端注射是一种微创的治疗中青年人股骨颈骨折的方法，有安全性高、费用低等优点。“,”Objective To discuss the effect of the cannulated compression screw internal fixation combined with platelet rich plasma(PRP)injection by the fracture for the treatment of femoral neck fracture in mid -age patients.Methods The fracture healing and complications after the operation of 25 mid -age patients who suffered from femoral neck fracture and received the cannulated compression screw internal fixation combined with autologous PRP injection were analyzed.Results 12 -40 months after operation,3 patients developed osteonecrosis of the femoral head and 2 patients with fracture nonunion.Conclusion The cannulated compression screw internal fixation combined with autologous PRP injection is an effective method to treat femoral neck fracture in mid -age patients.The operation is minimal invasive,relatively easy technique,low expense and short length of hospitalization,etc.