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设计合成了一种新型药物载体-多羧基官能团的聚酰胺-胺型高分子化合物。通过多次麦克儿(Michael)加成、氨解及水解等一系列反应,得以完成。所得最终产物3,5 代羧酸盐的化学结构,已经红外光谱及核磁共振氢谱证实,为新型高分子缀合药物的合成提供了工具化合物
Design and synthesis of a new drug carrier - polycarboxy functional polyamide - amine type polymer compounds. A series of reactions such as Michael addition, ammonolysis and hydrolysis were completed. The resulting final product 3, 5-carboxylate chemical structure has been confirmed by IR and 1H nuclear magnetic resonance spectroscopy for the synthesis of new polymer conjugates provide a tool compound