论文部分内容阅读
目的:研究汉族人群中、重度牙周炎与冠心病的相关性并初步探讨白细胞介素17在二者相关性中的可能作用。方法:检测和分析40名健康者(健康组)、40例中、重度牙周炎患者(牙周炎组)、28例冠状动脉粥样硬化性心脏病患者(冠心病组)及47例患冠心病伴中、重度牙周炎的患者(冠心病+牙周炎组)血清白细胞介素17水平、血脂水平(血清低密度脂蛋白、高密度脂蛋白、胆固醇、总胆固醇和甘油三酯)和牙周临床指数(附着丧失、探诊深度和探诊出血)。结果:单因素方差分析结果显示,健康组、牙周炎组、冠心病组及牙周炎+冠心病组的血清白细胞介素17水平分别为(13.01±1.23)、(24.45±2.13)、(59.90±2.23)和(68.87±3.43)ng/L,各组血清白细胞介素17间的差异具有统计学意义(P<0.05),且经协方差分析校正年龄、受教育状况、血压和体重指数后显示,各组血清白细胞介素17水平间的差异仍具有统计学意义(P<0.05)。多元Logistic回归分析结果显示,中、重度牙周炎患者发生冠心病的可能性高于牙周健康者,其发生冠心病的相对风险率比值比为2.416(P=0.039;95%CI:1.126-6.659)。经协方差分析校正年龄、受教育状况、血压和体重指数后,各组血清总胆固醇水平间差异仍具有统计学意义(P=0.018)。结论:严重的牙周感染可能通过改变白细胞介素17水平,影响全身炎症反应和冠心病的发生及发展,可能是冠心病事件的危险因素之一。
Objective: To study the association between severe periodontitis and coronary heart disease in Han population and to explore the possible role of interleukin-17 in their correlation. Methods: Forty healthy subjects (healthy group), 40 moderate and severe periodontitis patients (periodontitis group), 28 patients with coronary atherosclerotic heart disease (CHD group) and 47 patients Serum interleukin-17 levels, blood lipid levels (serum low density lipoprotein, high density lipoprotein, cholesterol, total cholesterol and triglycerides) in patients with coronary heart disease complicated with severe periodontitis (coronary heart disease + periodontitis group) And periodontal clinical index (loss of attachment, probing depth and probing bleeding). Results: The results of one-way ANOVA showed that serum interleukin-17 levels in healthy group, periodontitis group, coronary heart disease group and periodontitis + coronary heart disease group were (13.01 ± 1.23) and (24.45 ± 2.13) and 59.90 ± 2.23) and (68.87 ± 3.43) ng / L, respectively. The differences of serum interleukin 17 between the two groups were statistically significant (P <0.05) .According to covariance analysis, age, education level, blood pressure and body mass index The results showed that there was still a statistically significant difference in serum interleukin-17 levels between groups (P <0.05). Multivariate logistic regression analysis showed that the relative odds ratio of coronary heart disease was 2.416 (P = 0.039; 95% CI: 1.126-fold) in patients with moderate or severe periodontitis who were more likely to have coronary heart disease than those with periodontal health 6.659). After adjusting for age, education status, blood pressure and body mass index by covariance analysis, the differences of serum total cholesterol levels in each group were still statistically significant (P = 0.018). Conclusion: Serious periodontal infection may be one of the risk factors of coronary heart disease by changing the level of interleukin-17, affecting the systemic inflammatory response and the occurrence and development of coronary heart disease.