论文部分内容阅读
心肌顿抑(Myocardial stunning),是指缺血但未坏死的心肌功能障碍;心肌形态和超微结构仍正常,但长时间生化异常(如心肌ATP浓度下降)。可能发生心室功能障碍,例如短暂心肌缺血发作后的心肌顿抑使室壁动作异常加重。心肌顿抑不应与心肌冬眠Hibernating myocardium)相混淆,后者是指“冠脉血流减少引起的休息时左室功能持久性减退”,系因慢性心肌缺血引起机械功能减退,是心外膜冠脉阻塞的结果。当冠脉成形术或冠脉旁路移植术使慢性心肌缺血缓解后,其机械功能可完全恢复正常。相反,心肌顿抑则是短暂心肌缺血引起的心肌功能暂时抑制。
Myocardial stunning refers to myocardial dysfunction that is ischemic but not necrotic; myocardial morphology and ultrastructure remain normal, but long biochemical abnormalities (such as decreased myocardial ATP concentration). Ventricular dysfunction may occur, such as myocardial stunning after transient myocardial ischemia makes the wall abnormalities worse. Myocardial stunned should not be confused with Hibernating myocardium, which refers to “persistent loss of left ventricular function at rest due to reduced coronary blood flow,” which is caused by a decrease in mechanical function due to chronic myocardial ischemia Membrane coronary occlusion results. When the coronary angioplasty or coronary artery bypass graft mitigation of chronic myocardial ischemia, its mechanical function can be completely restored to normal. In contrast, myocardial stunning is a temporary inhibition of myocardial function caused by transient myocardial ischemia.