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目的研究高渗氯化钠羟乙基淀粉40注射液(霍姆)用于经尿道前列腺电切术(TURP)时预防电切综合征(TURS)的效果与安全性。方法选择前列腺增生症(BPH)患者40例,随机分为A、B两组,每组各20例。A组(HSH组)输高渗氯化钠羟乙基淀粉40注射液250 ml,B组(HS组)输羟乙基淀粉注射液,观察两组间一般生命体征,并抽取静脉血检测手术前后血红蛋白(Hb)、红细胞比容(HCT)及电解质,记录麻醉前及麻醉5、10、15 min及术毕的平均动脉压(MAP)。结果两组Hb、HCT和血清电解质手术前后及组间比较差异均无统计学意义,两组MAP在麻醉后5、10、15 min及术毕4个时点较麻醉前均明显降低(P<0.05),且A组MAP在麻醉后4个时点均高于B组(P<0.05)。结论霍姆250 ml用于TURP预防TURS是有效、安全的。
Objective To investigate the efficacy and safety of hypertonic sodium chloride hydroxyethyl starch 40 injection (TURP) in preventing transurethral resection syndrome (TURS). Methods Forty patients with benign prostatic hyperplasia (BPH) were randomly divided into A and B groups, 20 cases in each group. A group (HSH group) of hypertonic sodium chloride hydroxyethyl starch injection of 250 ml, B group (HS group) of hydroxyethyl starch injection, observe the general signs of vital signs between the two groups and venous blood test Before and after the hemoglobin (Hb), hematocrit (HCT) and electrolyte, before anesthesia and anesthesia 5,10,15 min and the mean arterial pressure (MAP). Results There were no significant differences in Hb, HCT and serum electrolytes between the two groups before and after operation and the two groups were significantly lower than those before anesthesia at 5, 10, 15 min and 4 postoperatively (P < 0.05), and MAP of group A was higher than that of group B at 4 time points after anesthesia (P <0.05). Conclusion Holm 250 ml is effective and safe for TURP prevention of TURS.