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目的评估血浆纤维蛋白原(FIB)在区分卵巢良恶性肿瘤的临床应用价值,并对其在妇科临床上的应用做出较为客观、全面的评价。方法采用回顾性研究的方法收集行手术住院治疗的盆腔脓肿、卵巢良性肿瘤及卵巢恶性肿瘤患者共198例作为研究对象,分别检测患者血浆FIB、CA125、D-D和PLT水平并进行比较。结果 3种疾病中血浆FIB增高发生率差异有统计学意义(P<0.05),盆腔脓肿增高发生率最高(68.42%),卵巢恶性肿瘤次之(27.94%),良性肿瘤最低(6.80%);3种疾病血浆FIB、CA125、D-D和PLT水平的差异有统计学意义(P<0.05),FIB、D-D和PLT水平在盆腔脓肿患者的血浆中均值最高,而CA125在卵巢恶性肿瘤患者血浆中的水平最高;此外,随着卵巢恶性肿瘤分期的不断进展,血浆FIB浓度异常者所占比例也逐渐增加。结论血浆FIB可为卵巢良恶性肿瘤的鉴别及诊断提供参考依据。
Objective To evaluate the clinical value of fibrinogen (FIB) in differentiating benign and malignant ovarian tumors and to make a more objective and comprehensive evaluation of its clinical application in gynecology. Methods A total of 198 cases of pelvic abscess, benign ovarian tumor and malignant ovarian tumor were collected by retrospective study. The levels of FIB, CA125, D-D and PLT in plasma were detected and compared. Results The incidence of plasma FIB increased in the three diseases (P <0.05). The incidence of pelvic abscess was the highest (68.42%), followed by malignant ovarian (27.94%) and lowest (6.80%). The plasma FIB, CA125, DD and PLT levels in the three diseases were significantly different (P <0.05). The levels of FIB, DD and PLT were the highest in the plasma of patients with pelvic abscess, while the levels of CA125 in the plasma of patients with ovarian cancer The highest level; In addition, with the continuous progress of staging of ovarian cancer, the proportion of patients with abnormal plasma FIB concentrations also gradually increased. Conclusion Plasma FIB can provide a reference for the identification and diagnosis of benign and malignant ovarian tumors.