论文部分内容阅读
目的探究灵芝孢子预防原发性肝癌根治术后复发的作用。方法采用完全随机对照的前瞻性临床研究,60例行根治切除的原发性肝癌患者随机分为术后常规治疗组和灵芝孢子治疗组,随访2年,观察术后无瘤生存率(DFS)、总体生存率(OS)和灵芝孢子的安全性。结果两组患者年龄、性别构成比、肿瘤大小以及术前AFP>20ng/ml、微血管侵犯、肿瘤卫星结节、乙肝感染、肝硬化患者比例的差异无统计学意义;术后抗病毒治疗患者比例以及术中输血、住院时间比较,差异无统计学意义(P<0.05)。术后常规治疗组和灵芝孢子治疗组的2年无瘤生存率分别为53.3%和70.0%(P=0.034),2年总生存率分别为60.0%和83.3%(P=0.023),差异有统计学意义。术后两组患者的并发症和药物副反应发生率无显著性差异(P=0.371)。结论灵芝孢子可以减少肝癌根治术后复发,安全有效。
Objective To explore the effect of Ganoderma lucidum spores on the prevention of recurrence of primary liver cancer after radical operation. Methods A totally randomized controlled prospective clinical study of 60 patients with primary liver cancer undergoing radical resection was randomly divided into routine treatment group and Ganoderma lucidum spores treatment group. The follow-up was 2 years. The postoperative tumor-free survival (DFS) , Overall survival (OS) and ganoderma lucidum spore safety. Results There was no significant difference in age, sex ratio, tumor size, preoperative AFP> 20ng / ml, microvascular invasion, tumor satellite nodules, hepatitis B infection and cirrhosis. The proportion of patients with postoperative antiviral therapy There was no significant difference between the two groups (P <0.05). The 2-year disease-free survival rates of the conventional and Ganoderma lucidum spores treatment groups were 53.3% and 70.0% (P = 0.034), respectively, and the 2-year overall survival rates were 60.0% and 83.3% (P = 0.023) Statistical significance. There was no significant difference in the incidence of postoperative complications and side effects between the two groups (P = 0.371). Conclusion Ganoderma lucidum spores can reduce the recurrence of liver cancer after radical surgery, safe and effective.