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目的探讨B超对当归补血汤复方及单味药治疗兔血吸虫病肝纤维化效果评价的价值。方法建立家兔血吸虫性肝纤维化模型,并将实验动物分成四组,其中三组分别用从当归、黄芪、当归加黄芪中提取的口服液结合吡喹酮进行治疗,对照组只给予吡喹酮进行病原学治疗。再用B超声像图评估当归、黄芪和当归补血汤治疗血吸虫病肝纤维化的效果。结果治疗A组(当归)、B组(黄芪)和C组(当归补血汤)均对兔血吸虫病肝纤维化有一定的疗效,其中C组(当归补血汤)的疗效最好,治疗前后肝长径、厚径、横径、PV内径测值均有显著性意义(P<0.05)。结论当归补血汤对血吸虫病肝纤维化的治疗作用优于单味药当归或黄芪。
Objective To explore the value of B-ultrasound in the evaluation of the effect of Danggui Buxue Decoction and single herb on liver fibrosis in rabbits with schistosomiasis. METHODS: A rabbit liver schistosomiasis fibrosis model was established. The experimental animals were divided into four groups. The three groups were treated with praziquantel combined with oral liquids extracted from Angelica Sinensis, Radix Astragali, Angelica sinensis and Radix Astragali. The control group was given only piquiquine. Ketones are treated with etiology. Then B ultrasound images were used to evaluate the effects of Angelica sinensis, Huangqi and Danggui Buxue Decoction on schistosomiasis liver fibrosis. Results Treatment group A (Angelica), group B (Huangqi) and group C (Danggui Buxue Decoction) all had certain curative effect on hepatic fibrosis of schistosomiasis in rabbits. Among them, group C (Danggui Buxue Decoction) had the best curative effect and liver before and after treatment. Long-diameter, thick-diameter, transverse-diameter, and PV inner diameters were all significant (P<0.05). Conclusion Danggui Buxue Decoction has better therapeutic effect on schistosomiasis liver fibrosis than single herb Angelica sinensis or Radix Astragali.