胰岛素抵抗(insulin resistant;IR)是指机体对一定量胰岛素的生物学效应低于正常水平的一种现象。由于各种原因使胰岛素作用的靶组织(主要为肝、脂肪、骨骼肌、血管内皮细胞等)对胰岛素利用的效率降低。在早期,胰岛β细胞为使血糖维持正常而代偿性分泌过多的胰岛素(即高胰岛素血症)。由于胰岛β细胞分泌的增加或血液循环中存在胰岛素拮抗物及胰岛素靶细胞缺陷等因素,均可能促成胰岛素抵抗现象的产生。现有研究表明胰岛素抵抗,自身并不直接促成动脉粥样硬化,胰岛素抵抗通过加剧血脂障碍及其他代 Insulin resistant (IR) refers to the body’s biological effects on a certain amount of insulin below a normal level of a phenomenon. The efficiency of insulin utilization by insulin target tissues (mainly liver, fat, skeletal muscle, vascular endothelial cells, etc.) is reduced for a variety of reasons. In the early stages, islet beta cells are insulin that compensates for excessive secretion (ie hyperinsulinemia), which maintains normal blood glucose. Due to the increased secretion of pancreatic β-cells or the existence of blood circulation in insulin antagonist and insulin target cell defects and other factors, may lead to insulin resistance phenomenon. Existing research shows that insulin resistance, itself does not directly contribute to atherosclerosis, insulin resistance by aggravating dyslipidemia and other generations