论文部分内容阅读
利福平的分子中有一共轭双键、酮基和醛亚胺基,可用各种方法进行分光光度测定。Eugenin等报道了体液中药物的分光光度法和微生物测定法,但是这些方法不适用于抗生素合并用药时的分析。本文根据酮基与苯肼反应生成黄色利福平苯腙的原理,设计一种简单的测定方法。标准溶液为100μg/ml的利福平甲醇溶液。胶囊剂及片剂的测定:秤取每片含150mg利福平的药片10片或胶囊10颗,计算其平均重量。另秤取相当于25mg利福平的粉末置于分液漏斗中,加入蒸馏水
Rifampin molecules have a conjugated double bond, keto and aldimine, spectrophotometry can be used in various ways. Eugenin et al. Reported spectrophotometric and microbiological assays of drugs in bodily fluids, but these methods are not suitable for the analysis of antibiotic combinations. In this paper, based on the reaction of keto group and phenylhydrazine yellow rifampin phenylhydrazone principle, the design of a simple determination method. The standard solution is 100 μg / ml of rifampicin in methanol. Determination of capsules and tablets: Weigh 10 tablets or capsules containing 150 mg of rifampin per tablet and calculate the average weight. The other scales take the equivalent of 25mg rifampicin powder placed in separatory funnel, add distilled water