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在加拉碘铵麻痹，人工呼吸维持和甲基阿托品预防的大鼠上，梭曼ＦＳ０．１ｍｇ·ｋｇ－１ｉｍ（ｎ＝２４）或毒扁豆碱３０．０ｍｇ·ｋｇ－１ｉｖ（ｎ＝１８）使全部大鼠脑电图（ＥＥＧ）上出现早期持续很短的紧张性癫痫波和随后持续很长的阵挛性癫痫波．中枢＃ＦＳＮ＃ＦＫ受体激动剂烟碱１．０ｍｇ·ｋｇ－１ｉｖ（ｎ＝３８）和中枢Ｍ受体激动剂槟榔碱１５０ｍｇ·ｋｇ－１ｉｖ（ｎ＝４６）或匹鲁卡品３８０ｍｇ·ｋｇ－１ｉｖ（ｎ＝２４）能分别在ＥＥＧ癫痫波的特征，出现时间和持续时间上模拟出上述早期紧张性癫痫波和随后的阵挛性癫痫波．预先小剂量ｉｖ烟碱使中枢Ｎ受体脱敏或给小剂量Ｎ受体拮抗剂美加明保护中枢Ｎ受体后，梭曼只能引起潜伏期较长且持续很久的阵挛性癫痫波．胆碱酯酶抑制剂梭曼和毒扁豆碱较大剂量引起大鼠ＥＥＧ癫痫波可能的机理是过量的乙酰胆碱作用于潜伏期短，容易脱敏的Ｎ受体出现早期持续很短的ＥＥＧ紧张性癫痫波，又作用于潜伏期较长，不容易脱敏的Ｍ受体，出现稍后的ＥＥＧ阵挛性癫痫波
Sumanese FS 0.1 mg·kg -1 im (n = 24) or physostigmine 30.0 mg·kg -1 iv (n = 18) in rats treated with galarium iodine paralysis, artificial respiration maintenance and methyl atropine prevention A very short episode of tensional epilepsy occurred early in the whole rat electroencephalogram (EEG) and followed by a long wave of clonic epilepsy. Central #FSN#FK Receptor Agonist 1.0 mg·kg-1 iv (n=38) and Central M Receptor Agonist Arecoline 150 mg·kg-1 iv (n=46) or pilocarpine 380 mg·kg -1iv (n=24) can simulate the above-mentioned early tension epileptic wave and subsequent clonic epileptic wave respectively in the characteristics, appearance time and duration of EEG epileptic wave. After a small dose of iv nicotine in advance desensitizes the central N-receptor or protects the central N-receptor with a small dose of the N-receptor antagonist megamine, soman can only cause clonic seizure waves with a long incubation period and long duration. The possible mechanism of cholinesterase inhibitors soman and physostigmine in large doses of rat EEG epileptic waves is the excess acetylcholine action in the short incubation period, easy to desensitize the N-receptor early sustained short EEG tension epilepsy The wave also acts on M receptors with a long latency and is not susceptible to desensitization. Later EEG clonic epilepia waves appear.