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目的 :研究海口市吸毒人群病毒与甲～庚型肝炎病毒感染状况。方法 :对 2 2 1例吸毒者进行不同因素分析 ,采用巢式 PCR法检测血清中的 TTV DNA,对一株 TTV部分基因序列进行了测定 ;用 EL ISA法检测甲～庚型肝炎病毒。结果 :2 2 1名吸毒人群中 TTV DNA与甲～庚型肝炎病毒感染率分别为 HBV45 .7%、 TTV DNA31.6 %、 HCV11.8%、HGV10 .4%、 HEV2 .2 %、HAV0 .4% ;静脉毒瘾者、有非固定婚外性伴侣等因素与 TTV、HBV、HCV感染有关 ;TTV与甲～庚型肝炎病毒均存在合并感染 ;一株 TTV DNA序列与 Gen Bank中主要序列核苷酸同源性大于 98%。结论 :吸毒人群是 TTV和肝炎病毒感染的高危人群 ,静脉毒瘾者、有非固定性伴侣是 TTV、HBV、HCV传播的重要因素 ,TTV还存在非血源性传播途径 ,TTV与甲～庚型肝炎合并感染后引起的作用尚须作进一步研究
Objective: To study the drug-induced human population virus and hepatitis A-G virus infection in Haikou City. Methods: Twenty-two drug abusers were analyzed by different factors. The serum TTV DNA was detected by nested PCR and the sequence of one TTV gene was determined. ELASA was used to detect the hepatitis A ~ G virus. Results: The prevalences of TTV DNA and A ~ G hepatitis B virus were 24.5% HBV, 31.6% TTV DNA, 11.8% HCV, 10.4% HGV, 2.0% HEV2. 4%; intravenous drug addicts, non-fixed extra-marital sexual partners and other factors related to TTV, HBV, HCV infection; TTV and hepatitis A ~ Hepatitis virus are co-infection; a TTV DNA sequence and Gen Bank major sequence Nucleotide homology is greater than 98%. Conclusion: The drug addicts are at high risk of TTV and hepatitis B virus infection. Intravenous drug addicts and non-fixed couples are important factors of TTV, HBV and HCV transmission. Non-blood-borne transmission of TTV exists. Hepatitis co-infection caused by the role still needs further study