AIM: To determine the extent of colorectal cancer(CRC) mortality and the association between demographic characteristics and CRC mortality in Inner Mongolia.METHODS: Data were collected from the Death Registry System, maintained by the Inner Mongolia Centers for Disease Control and Prevention, from 2008 to 2012. Deaths were classified according to the International Classification of Disease, 10th Revision. Years of life lost, average years of life lost(AYLL), and mortality were calculated over the five years between 2008 and 2012. A conditional logistic regression model was used to analyze the association between marital status, occupational status, education level, area of residence, and the risk of CRC.RESULTS: The AYLL of CRC was 17.39 years. The average mortality of CRC was 5.6/100000. People living in urban areas and having a higher education level had a significantly higher risk of CRC(OR = 1.74 and 95%CI: 1.29-2.35, P < 0.001 and OR = 2.39, 95%CI: 1.76-3.25, P < 0.001, respectively). People who were employed had a lower risk of CRC(OR = 0.64, 95%CI: 0.48-0.86, P = 0.003). The mortality of CRC was positively correlated with the education level(P < 0.001). No statistically significant association was observed between marital status and CRC risk(P = 0.259).CONCLUSION: Living in urban areas, higher education level and unemployment are associated with CRC mortality in Inner Mongolia. AIM: To determine the extent of colorectal cancer (CRC) mortality and the association between demographic characteristics and CRC mortality in Inner Mongolia. METHODS: Data were collected from the Death Registry System, maintained by the Inner Mongolia Centers for Disease Control and Prevention, from 2008 to 2012. Deaths were classified according to the International Classification of Disease, 10th Revision. Years of life lost, average years of life lost (AYLL), and mortality were calculated over the five years between 2008 and 2012. A conditional logistic regression model was used to analyze the association between marital status, occupational status, education level, area of ​​residence, and the risk of CRC.RESULTS: The AYLL of CRC was 17.39 years. The average mortality of CRC was 5.6 / 100000. People living in urban areas and having a higher education level had a significantly higher risk of CRC (OR = 1.74 and 95% CI: 1.29-2.35, P <0.001 and OR = 2.39, 95% CI: 1.76-3.25, P <0.001, respectiv The people who were employed had a lower risk of CRC (OR = 0.64, 95% CI: 0.48-0.86, P = 0.003). The mortality of CRC was positively correlated with the education level (P <0.001). Significant association was observed between marital status and CRC risk (P = 0.259) .CONCLUSION: Living in urban areas, higher education level and unemployment are associated with CRC mortality in Inner Mongolia.