5型磷酸二酯酶广泛存在于肾脏和血管,近来还被发现存在于心脏中。西地那非是一种5型磷酸二酯酶抑制剂,临床上广泛用于勃起功能障碍的治疗;脑利钠肽为一心源性产物,可扩张血管、舒张心脏、并有利尿作用,两者均通过环鸟嘌呤核苷酸起作用。因此临床中,设想通过加强肾性环鸟嘌呤核苷酸,5型磷酸二酯酶的慢性抑制可提高外源性脑利钠肽的肾性作用。为此,Chen HH等人进行了一项研究,在两组依靠起博诱导的慢性心衰狗中, Type 5 phosphodiesterase is found extensively in the kidneys and blood vessels and has recently been found to be present in the heart. Sildenafil is a type 5 phosphodiesterase inhibitor that is clinically widely used in the treatment of erectile dysfunction. Brain natriuretic peptide is a cardiogenic product that dilates blood vessels, relaxes the heart, and has diuretic effects. Two Cyclic guanine nucleotides through the role. Therefore, in clinical practice, it is envisaged that the renal effects of exogenous brain natriuretic peptide may be enhanced by enhancing the chronic inhibition of renal cyclic guanine nucleotide and type 5 phosphodiesterase. To this end, Chen HH, who conducted a study in two groups rely on poker-induced chronic heart failure dogs,