颞叶内侧癫痫(MTLE)是指与颞叶内侧海马结构相关病理导致的癫痫,临床主要表现为复杂部分性发作,病理以海马硬化为典型特征,动物实验证明短暂或持续的癫痫发作可导致脑内神经元的凋亡和多种凋亡相关基因的表达,如凋亡调节蛋白、caspase家族成员,caspase -3是细胞凋亡的信号转导通路的关键效应酶,caspase-9和caspase-8启动的内外源性凋亡途径均与之密切相关因 Temporal lobe medial epilepsy (MTLE) refers to the temporal lobe hippocampal formation associated with the pathology of epilepsy, the clinical manifestations of complex partial seizures, pathological features of hippocampal sclerosis typical animal experiments show that short-term or sustained seizures can lead to brain The apoptosis of inner neurons and the expression of various apoptosis-related genes, such as apoptosis regulatory protein, caspase family member, caspase-3 is the key effector of apoptosis signal transduction pathway, caspase-9 and caspase-8 The initiation of both extrinsic and apoptotic pathways are closely related