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采用不同的血液动力学方法,对犬蛛网膜下腔出血(SAH)后引起的症状性脑血管痉挛(CVS)进行治疗。我们发现:①等容稀释加胞二磷胆碱和多巴酚丁胺疗法与人工扩容疗法疗效相同(P>005),但与等容稀释加胞二磷胆碱疗法相比,疗效有显著性差异(P<005),前者尤其适用于扩容稀释禁忌证的病人;②稀释剂中加入胞二磷胆碱,可使红细胞变形能力增加,改善脑微循环;③大剂量应用多巴胺升压,部分病例可使CVS加重,临床应慎用。
Different hemodynamic methods were used to treat symptomatic cerebral vasospasm (CVS) caused by subarachnoid hemorrhage (SAH) in dogs. We found that: ① equal volume dilution plus citicoline and dobutamine therapy and artificial dilatation therapy the same efficacy (P> 0 05), but with isodose dilution plus citicoline treatment, efficacy (P <0 05), the former is especially suitable for patients with dilatation dilatation contraindications; ② adding citicoline in the diluent can make the erythrocyte deformability increase, improve the cerebral microcirculation; ③ high-dose application Dopamine boost, CVS may increase in some cases, should be used with caution.