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目的对育龄人群进行地中海贫血筛查以预防重症地贫患儿的出生。方法对2009年1月1日至2011年12月31日本院产科门诊、婚前检查门诊的就诊者进行地中海贫血(地贫)筛查,以血常规MCV(平均红细胞体积)和/或血红蛋白电泳进行初筛,阳性者建议基因检测。结果接受电泳检查的人群中,α地贫的检出为20.3%,β地贫的检出率为11.3%,电泳与基因结果的符合率β地贫较高。结论育龄人群进行地中海贫血筛查,对优生优育,减轻社会的经济负担有重要的意义。
Objective To screen for thalassemia in children of childbearing age to prevent the birth of children with severe thalassemia. Methods Thalassemia (thalassemia) screening was conducted in obstetric outpatient clinics and prenuptial checkup clinics in our hospital from January 1, 2009 to December 31, 2011. The patients were treated with blood routine MCV (average erythrocyte volume) and / or hemoglobin electrophoresis Preliminary screening, positive suggested genetic testing. Results Among the population of patients who underwent electrophoresis, the detection rate of α thalassemia was 20.3%, the detection rate of β thalassemia was 11.3%, and the coincidence rate of β-thalassemia and electrophoresis was higher. Conclusion The screening of thalassemia in children of childbearing age is of great significance to prenatal and postnatal care and to alleviating the economic burden of the society.