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为探讨CD 44变异型(CD 44 v)在支气管粘膜上皮癌变过程中的表达及其意义,应用免疫组化方法在含有肺鳞癌及其癌前病变的标本上观察了CD 44 v在肺鳞癌发生过程中出现表达的时间和频率。结果表明,癌旁正常支气管上皮细胞未见cD 44 v表达,在鳞状化生的支气管上皮细胞、轻→中→重度不典型增生、原位癌、浸润癌的CD 44 v表达的阳性率逐渐升高,阳性细胞也逐渐增多。表达CD 44 v的不典型增生的支气管上皮,其相应的鳞癌CD 44 v也呈阳性表达。结论:CD 44变异型可作为判断肿瘤发生可能性的有用标记物,在肺鳞癌的早期诊断中具有重要意义。
To investigate the expression and significance of CD44 variant (CD 44 v) during bronchial epithelial carcinogenesis, immunohistochemistry was used to examine CD 44 v in lung squamous cells on specimens containing lung squamous cell carcinoma and precancerous lesions. The time and frequency of expression occur during carcinogenesis. The results showed that the normal bronchial epithelial cells adjacent to the tumor had no expression of cD 44 v, and the positive rate of CD 44 v expression in squamous metaplastic bronchial epithelial cells, mild to moderate, severe atypical hyperplasia, carcinoma in situ, and invasive carcinoma gradually increased. Ascended, positive cells gradually increased. The atypical hyperplastic bronchial epithelium expressing CD44v also showed a positive expression of its corresponding squamous cell carcinoma CD44v. Conclusion: CD44 variant can be used as a useful marker to determine the possibility of tumorigenesis. It is of great significance in the early diagnosis of squamous cell carcinoma of the lung.