本文分析了进入英国医学研究委员会(MRC)ALL试验治疗的儿童急性淋巴细胞白血病(ALL)的长期随访资料,并估算了晚期复发的频率,以及导致这种复发的白血病类型及何种病人有这种危险。 材料和方法 病人来自1970～1984年在MRC ALL试验中治疗的儿童,随访时间均达10年以上,中数随访期18年。从骨髓片上取材抽提DNA,用聚合酶链反应(PCR)法扩增免疫球蛋 This article analyzes the long-term follow-up data of children with acute lymphoblastic leukemia (ALL) that entered the ALL Medical Treatment Committee (MRC) trial, and estimated the frequency of late recurrence, and the type of leukemia that causes this relapse and what patients have this Dangerous. Materials and Methods The patients from the 1970-1984 MRC ALL trial were followed up for more than 10 years and the median follow-up period was 18 years. Extraction of DNA from bone marrow slices and amplification of immunoglobulin by polymerase chain reaction (PCR)