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乙胺碘呋酮(胺碘酮)为抗心律失常药。在大剂量应用时,可发生一些严重的副作用。如角膜微粒沉淀、甲状腺功能失调、皮肤蓝色素沉着和光过敏等。近来有人报道还可引起急进性肺炎综合征。作者对13例服用胺碘酮的患者作了支气管肺泡灌洗(BAL),并对其中的巨噬细胞进行了电镜观察。其中8例出现了不能用其它药物反应来解释的肺浸润,余5例无肺病变征象(对照组)。肺炎组与对照组比较,前者肺功能检查(TLC、FVC 和 DLCO)的平均值低于正常;平均用药治疗的时间较短;药物的累积量较小;可是血中性白细胞的百分率在肺炎组与对照组之间无异。
Amiodarone (amiodarone) is an anti-arrhythmic drug. In high-dose applications, some serious side effects can occur. Such as corneal particle deposition, thyroid dysfunction, blue skin pigmentation and light allergies. It has recently been reported that can cause acute pneumonia syndrome. The authors performed bronchoalveolar lavage (BAL) on 13 patients taking amiodarone and observed the macrophages in these cells by electron microscopy. Of the 8 cases, pulmonary infiltrates, which could not be explained by other drug reactions, were observed in 5 cases, and the other 5 cases were non-pulmonary lesions (control group). Pneumonia group compared with the control group, the former pulmonary function tests (TLC, FVC and DLCO) mean was lower than the average; treatment time is shorter; the cumulative amount of drugs smaller; but the percentage of neutrophils in the pneumonia group No difference between the control group.