论文部分内容阅读
目的:观察杨桃果总黄酮(ACFTF)对正常大鼠和NG-硝基-L-精氨酸甲酯(L-NAME)致高血压大鼠血压的影响。方法:制备杨桃果总黄酮,分别用颈总动脉插管法连接MPA多媒体生物信号记录系统测定正常大鼠和ALC-nibp无创尾动脉压测量分析系统测定L-NAME致高血压大鼠,观察杨桃果总黄酮低、中、高(300、600、1 200mg·kg~(-1)·d~(-1))3个剂量组对大鼠给药前和给药后血压的影响。结果:在正常大鼠实验中,与空白对照组比较,高、中、低剂量3个给药组均在20min出现最大降压,SBP、DBP和MBP值有显著性差异(P<0.05,P<0.01)。在高血压大鼠实验中,与模型组比较,高剂量组和中剂量组第2周血压明显降低(P<0.05),低剂量组和中剂量组在第3周血压明显降低(P<0.05)。结论:杨桃果总黄酮中含有降血压活性成分,能降低正常大鼠和L-NAME致高血压大鼠的血压。
Objective: To observe the effect of carambola total flavone (ACFTF) on blood pressure in normal rats and NG-nitro-L-arginine methyl ester (L-NAME) -induced hypertension rats. Methods: The total flavonoids of carambola was prepared. The MPA multimedia biosignal recording system was connected by carotid artery cannulation to determine the normal rat and ALC-nibp noninvasive caudal arterial pressure measurement and analysis system to determine the L-NAME induced hypertensive rats. Effects of total flavonoids in three doses of low, medium and high doses (300,600,1 200 mg · kg -1 · d -1) on blood pressure in rats before and after administration. Results: Compared with the blank control group, the maximum blood pressure, the SBP, the DBP and the MBP in the three groups of high, medium and low dose groups all showed the largest decrease in 20 minutes (P <0.05, P <0.01). Compared with the model group, the blood pressure in the high-dose group and the middle-dose group decreased significantly in the second week (P <0.05), while the blood pressure in the low-dose group and middle-dose group decreased significantly in the third week (P <0.05) ). Conclusion: The total flavonoids of carambola contain hypotensive active ingredients, which can reduce the blood pressure of normal rats and L-NAME-induced hypertension rats.