真核基因的表达是一个复杂的过程,包括转录、pre-mRNA剪接、翻译等步骤。其中转录和pre-mRNA的剪接是基因表达中的两个重要环节,它们都要通过复杂的蛋白复合物来执行功能。目前研究发现这两个过程并不是绝对独立的,而是偶联在一起同时进行的。多种蛋白的偶联作用将二者联系在一起。RNA聚合酶Ⅱ、SKIP、SMN以及新近发现的人类P100蛋白不仅参与基因转录调节,同时它们在剪接加工中也具有相应的作用。 Eukaryotic gene expression is a complex process, including transcription, pre-mRNA splicing, translation and other steps. Among them, transcription and pre-mRNA splicing are two important aspects of gene expression, and they all perform their functions through complex protein complexes. The current study found that these two processes are not absolutely independent, but coupled together at the same time. The coupling of multiple proteins ties the two together. RNA polymerase II, SKIP, SMN, and the recently discovered human P100 protein are not only involved in gene transcription regulation, they also play a role in splicing.