目的:制备更昔洛韦肺部靶向微囊并测定其体外释放度。方法:以双乳化溶剂挥发法制备微囊;采用紫外分光光度法测定微囊的体外释药量,考察其体外释放度。结果:所制微囊外观圆整,平均粒径13.87μm;更昔洛韦检测浓度的线性范围为2～20μg·mL-1(r=0.999 9),平均回收率为99.96%(RSD=1.68%);包封率为63.85%,24h累积体外释放度约为40%。结论:更昔洛韦肺部靶向微囊具有良好的缓释性。 OBJECTIVE: To prepare ganciclovir-targeted pulmonary microcapsules and determine their in vitro release. Methods: The microcapsules were prepared by double-emulsion solvent evaporation method. The in vitro release of microcapsules was determined by ultraviolet spectrophotometry. Results: The average diameter of the microcapsules was 13.87μm. The linear range of the concentration of ganciclovir was 2 ~ 20μg · mL-1 (r = 0.999 9), the average recovery was 99.96% (RSD = 1.68 %); Encapsulation efficiency was 63.85%, 24h cumulative in vitro release of about 40%. Conclusion: Ganciclovir lung-targeted microcapsules have good sustained release.