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甲巯丙脯酸(captopril)为治疗肾性高血压的理想药物。作者报告1例成人肾性高血压患者使用甲巯丙脯酸后短期内出现锌缺乏综合征,经补锌治疗症状消失。 60岁成人多囊肾患者,因多种药物不能控制高血压而使用甲巯丙脯酸治疗。口服剂量50mg每日3次,血压自200/130降至130/90mmHg。肌酐清除率(Ccr)保持18ml/min。服药后3周病者诉述味觉丧失,6周后躯干、四肢出现苔癣样皮疹且呈进展性,并逐渐出现头发和阴毛脱落。减药量为12.5mg每日3次后皮损减轻,但血压上升到170/115mmHg,持
Captopril is the ideal drug for the treatment of renal hypertension. The authors report that zinc deficiency syndrome developed shortly after hypertrophy in adults with hypertriglyceridemia and disappeared after zinc supplementation. 60-year-old adult polycystic kidney disease patients, due to a variety of drugs can not control hypertension and the use of captopril treatment. Oral dose of 50mg three times daily, blood pressure from 200/130 to 130 / 90mmHg. Creatinine clearance (Ccr) was maintained at 18 ml / min. The patient complained about the loss of taste 3 weeks after taking the medication. After 6 weeks, the patient developed lichenoid rash on the trunk and limbs and gradually developed hair and pubic hair loss. Subtraction of 12.5mg 3 times a day after the lesion lessened, but the blood pressure rose to 170 / 115mmHg, holding