随着丙型肝炎病毒(HCV)研究的深入,HCV不仅是输血后肝炎的主要病因,而且涉及其他许多已知疾病,其中多数具有自身免疫的背景,为非肝脏疾病,如冷球蛋白血症、皮肤卟啉症、Sjogren’s综合征及膜性肾小球肾炎等。本文重点回顾HCV 感染与自身免疫性肝病的联系,以及HCV在有自身免疫背景的非肝脏疾病中的潜在作用。 With the progress of hepatitis C virus (HCV) research, HCV is not only the major cause of post-transfusion hepatitis, but also involves many other known diseases, most of which have the background of autoimmunity and are non-hepatic diseases such as cryoglobulinemia , Skin porphyria, Sjogren’s syndrome and membranous glomerulonephritis. This review focuses on the link between HCV infection and autoimmune liver disease and the potential role of HCV in non-liver disease with an autoimmune background.