论文部分内容阅读
戊四氮(pentylenetetrazole,PTZ)为中枢苯二氮(benzodiazepine,BDZ)受体超分子结构功能单位Cl~-通道阻断剂,具有致惊厥和致焦虑作用。抗PTZ惊厥效价,巳为多数作者用以评价抗焦虑药物的初筛法。可乐定不能显著拮抗PTZ惊厥,但可降低惊厥死
Pentylenetetrazole (PTZ) is a blocker of supramolecular structure and function unit of benzodiazepine (BDZ), which causes convulsion and anxiety. The anti-PTZ convulsion titer has been the screening method most authors use to evaluate anti-anxiety drugs. Clonidine did not significantly antagonize PTZ convulsions but could reduce convulsions