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目的:新近发现的脂肪因子CTRP9(C1q/TNF-related-protein-9)与脂联素(adiponectin,APN)有相似的结构,并有类似的代谢调节功能。本研究观察CTRP9对鼠离体主动脉环的舒张效果,探讨其对内皮细胞舒张功能的作用及机制。方法:取大鼠胸主动脉制备血管环进行常规试验,分组进行处理:对照组(K-H液)、APN组、APN+L-NAME组。然后收
OBJECTIVE: The newly discovered adipokine-like factor CTRP9 (C1q / TNF-related-protein-9) has a similar structure with adiponectin (APN) and has similar metabolic regulation functions. This study was to observe the effect of CTRP9 on the aortic ring relaxation in isolated rat aortic rings and to explore its effect on the diastolic function of endothelial cells. Methods: Vascular rings were prepared from the thoracic aorta of rats by routine test and divided into groups for treatment: control group (K-H solution), APN group and APN + L-NAME group. Then close